Impact of steatotic liver diseases on diabetes mellitus risk in patients with atrial fibrillation: a nationwide population study
Authors' conclusion
SLD confers an increased risk of new-onset DM in AF patients, especially in younger adults. Implementing management strategies to prevent DM in AF patients with SLD might mitigate the risk of DM and its potential impact on AF-related outcomes.
Study context
- Population
- Non-diabetic individuals who developed atrial fibrillation (AF) between 2010 and 2018, Korea; mean age 64.4 ± 13.0 years, 57.5% male
- Participants
- 195,195 individuals
- Exposure
- MASLD, MetALD or ALD vs non-SLD
- Non-SLDn = 108,918reference
- MASLDn = 71,795
- MetALDn = 7,644
- ALDn = 6,838
- Outcome
- Incident DM
- Follow-up
- Mean 6.0 ± 2.9 years
Methodological detailsnationwide, Korean National Health Insurance Service database
- Nationwide
- Korean National Health Insurance Service database
Main finding
As reported in the abstract
Each group vs Non-SLDAdjusted hazard ratio (95% CI)
MASLD
1.930(1.879–1.983)
MetALD
1.789(1.682–1.904)
ALD
1.932(1.817–2.054)
- Developed diabetes mellitus (DM) (all patients)
- 25,632 (13.0%)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Incident DM, age 20-39 years subgroupMASLDvs Non-SLD | 5.844 (4.501–7.587) | |
| Incident DM, age 20-39 years subgroupMetALDvs Non-SLD | 5.354 (3.681–7.787) | |
| Incident DM, age 20-39 years subgroupALDvs Non-SLD | 7.033 (4.660–10.615) | |
| 0.050.21520Adjusted hazard ratio (log scale) |
Original publication
Impact of steatotic liver diseases on diabetes mellitus risk in patients with atrial fibrillation: a nationwide population study. Cardiovasc Diabetol. Published 7 June 2025. doi:10.
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