Type 2 diabetes worsens the outcome of ischemia/reperfusion in female STEMI patients and female db/db mice with heart failure with preserved ejection fraction (HFpEF) cardiometabolic phenotype
Authors' conclusion
In diabetic women, multiple factors beyond reperfusion delays exacerbate acute myocardial injury. This necessitates the development of sex-specific strategies to manage the cardiovascular complications of diabetic HFpEF. The db/db mouse model provides a relevant preclinical tool for future research as it mimics human T2D-associated HFpEF and STEMI outcome.
Study context
- Population
- Female STEMI patients undergoing primary PCI; female db/db mice (HFpEF cardiometabolic phenotype)
- Participants
- 40 vs 40
- Comparison
- T2D vs non-diabetic controls in female STEMI patients undergoing primary percutaneous coronary intervention (pPCI); female db/db mice vs non-diabetic controls
- T2Dn = 40
- Non-diabetic controlsn = 40reference
- Outcome
- Early outcomes after pPCI
Methodological detailsintegrated clinical and pre-clinical approach
- Integrated clinical and pre-clinical approach
Main finding
As reported in the abstract
- Significantly higher mortality in T2D vs non-diabetic controls, irrespective of door-to-balloon (DTB) time
- Impaired left ventricular function post-pPCI in T2D
- Increased implantable cardioverter-defibrillator (ICD) implantation rates in T2D
Observational data: associations, not effects.
Further findings
Inflammatory, glycaemic and organ-damage markers
- Elevated inflammatory markers, acute hyperglycaemia and evidence of cardio-hepatic damage in T2D
Db/db mice: ischemia-reperfusion injury
- Analogous T2D-associated pathophysiology, incl. increased ischemia-reperfusion injury exacerbated by metabolic disturbances in myocardium, liver and skeletal muscle vs non-diabetic controls
Original publication
Type 2 diabetes worsens the outcome of ischemia/reperfusion in female STEMI patients and female db/db mice with HFpEF cardiometabolic phenotype. Cardiovasc Diabetol. Published 7 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →