Oral-gut microbial transmission promotes diabetic coronary heart disease
Authors' conclusion
Our findings not only uncover dysregulation of the oral-gut microbiota axis in diabetes patients but also highlight the pivotal intermediary role of the increased abundance of oral F. nucleatum and gut Lactobacillus in exacerbating MIRI. Targeting the oral-gut microbiota axis emerges as a potent strategy for preventing and treating DCHD. Oral-gut microbial transmission constitutes an intermediate mechanism by which diabetes influences myocardial injury, offering new insights into preventing acute events in diabetic patients with coronary heart disease.
Study context
- Population
- Patients with diabetic coronary heart disease (DCHD); streptozotocin-treated C57BL/6 mice with diabetic myocardial ischemia-reperfusion injury (MIRI)discovery cohort n = 183
- Outcome
- Oral-gut microbial signatures in DCHD and effect on diabetic MIRI
Methodological detailsdiscovery and validation cohorts, metagenomic sequencing and qPCR, mouse experiments, Oral (tongue-coating) and fecal specimens subjected to metagenomic sequencing and qPCR, Diabetic MIRI induced with streptozotocin in C57BL/6 mice; antibiotic pre-treatment followed by gavage with F. nucleatum or fecal microbiota from DCHD patients
- Discovery and validation cohorts
- Metagenomic sequencing and qPCR
- Mouse experiments
- Oral (tongue-coating) and fecal specimens subjected to metagenomic sequencing and qPCR
- Diabetic MIRI induced with streptozotocin in C57BL/6 mice; antibiotic pre-treatment followed by gavage with F. nucleatum or fecal microbiota from DCHD patients
Main finding
As reported in the abstract
- Potential microbial biomarkers in DCHD: oral Fusobacterium nucleatum and gut Lactobacillus, Eubacterium and Roseburia faecis
- Oral F. nucleatum and gut Lactobacillus increased in DCHD patients, with positive correlation between the two
- In hyperglycaemic mice, augmented oral F. nucleatum with oral-gut axis imbalance: increased coexistence of F. nucleatum and Lactobacillus
- Elevated cardiac miRNA-21 and greater myocardial damage (TTC, HE, TUNEL staining), contributing to exacerbated MIRI
Original publication
Oral-gut microbial transmission promotes diabetic coronary heart disease. Cardiovasc Diabetol. Published 5 April 2024. doi:10.
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