Vitamin D Status, Vitamin D Receptor Polymorphisms, and Risk of Type 2 Diabetes: A Prospective Cohort Study
An erratum to this article was published (J Clin Endocrinol Metab, 13 Aug 2024 ↗)
Authors' conclusion
Higher serum 25(OH)D concentrations were associated with lower T2D risk across the glycemic spectrum below the threshold for diabetes, and the relations in prediabetes were modified by VDR polymorphisms. Improving the lipid profile, mainly triglycerides, accounted for part of the favorable associations.
Study context
- Population
- Participants without T2D at baseline from the UK Biobank, analysed by glycemic status (normoglycemia, prediabetes) and HbA1c levels
- Participants
- 379,699 participants
- Exposure
- Serum 25D ≥75 nmol/L vs <25 nmol/L
- Outcome
- Incident T2D
- Follow-up
- Median 14.1 years
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
median 14.1 years
25(OH)D ≥ 75 nmol/L vs 25(OH)D < 25 nmol/LMultivariable-adjusted HR (95% CI)
Normoglycemia
0.62(0.56–0.70)
Prediabetes
0.64(0.58–0.70)
- Developed T2D, normoglycemia
- 6315
- Developed T2D, prediabetes
- 9085
Observational data: associations, not effects.
Further findings
Interaction between 25(OH)D and vitamin D receptor (VDR) polymorphisms, prediabetes
- Reduced HR of T2D with higher 25(OH)D more prominent in T allele carriers of rs1544410
- P for interaction = 0.017
Mediation by triglyceride levels
- Proportion mediated, normoglycemia
- 26%
- Proportion mediated, prediabetes
- 34%
Original publication
Vitamin D Status, Vitamin D Receptor Polymorphisms, and Risk of Type 2 Diabetes: A Prospective Cohort Study. J Clin Endocrinol Metab. Published 4 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →