Influence of diabetes and other risk factors on in-hospital mortality following kidney transplantation: an analysis of the Spanish National Hospital Discharge Database from 2016 to 2020
Authors' conclusion
The COVID-19 pandemic led to a decrease in the number of transplants. Patients with T1D have more rejection of the transplanted organ than patients with T2D. Fewer women with T2D undergo KT. The presence of T1D is a risk factor for IHM.
Study context
- Population
- Kidney transplant (KT) recipients admitted to Spanish hospitals, 2016–2020, Spanish National Hospital Discharge Database
- Participants
- 14,594 KTs
- Exposure
- T1D vs T2D vs no diabetes among KT recipients
- Outcome
- In-hospital mortality (IHM)
Methodological detailsnationwide discharge database, multivariable logistic regression
- Nationwide discharge database
- Multivariable logistic regression
Main finding
As reported in the abstract
IHM
Each group vs without diabetesOdds ratio (95% CI)
T1D
2.6(1.36–5.16)
T2D
0.86(0.61–1.2)
Observational data: associations, not effects.
Further findings
| Outcome | T1D | T2D |
|---|---|---|
| Share of KTs by diabetes status | 3.72% | 22.28% |
| KT rejection | 8.09% | 5.57% |
Share of KTs by diabetes status
- Number of KTs rose 2016–2019 and decreased 2019–2020 in all groups
KT complications in T2D, 2016 vs 2020
- KT complications in T2D increased from 21.08% in 2016 to 34.17% in 2020
- P < 0.001
Comorbidity
- T2D had significantly more comorbidity than T1D and without diabetes
- P < 0.001
KT rejection
- Rejection significantly more frequent in T1D than T2D
COVID-19 in KT recipients, 2020
- COVID-19 recorded in KTs performed in 2020
- 26 out of the 2444
- COVID-19 among deceased in 2020
- 6 of the 39 (15.38%)
- COVID-19 among survivors
- 0.83%
Original publication
Influence of diabetes and other risk factors on in-hospital mortality following kidney transplantation: an analysis of the Spanish National Hospital Discharge Database from 2016 to 2020. BMJ Open Diabetes Res Care. Published 3 April 2024. doi:10.
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