Role of kidney function on Nrf2 messenger RNA (mRNA) levels in type 2 diabetes
Authors' conclusion
The observed dysregulation in the Nrf2-Keap1 axis and the unique expression pattern of miRNA30e-5p in DKD underscore the need for more focused research in this domain that can help identify novel intervention strategies for DKD in patients with type 2 diabetes.
Study context
- Population
- Non-dialysis patients with T2D with or without diabetic kidney disease (DKD), and control subjects
- Participants
- 99 patients
- Comparison
- T2D with DKD vs T2D without DKD vs controls
- DKDn = 33
- No DKDn = 33
- Controlsn = 33reference
- Outcome
- Nrf2 mRNA levels
Main finding
As reported in the abstract
- No difference in Nrf2 expression between No DKD and Controls
- DKD vs No DKD: P = 0.01
- DKD vs Controls: P = 0.02
Observational data: associations, not effects.
Further findings
Keap1 expression levels
- Keap1 expression significantly higher in patients with and without DKD than in controls
miRNA 30e-5p expression (of 6 microRNAs (miRNAs) studied)
- miRNA 30e-5p showed differential expression, markedly reduced in patients with DKD
- P = 0.007
Correlation of Nrf2 mRNA with estimated glomerular filtration rate (eGFR) in DKD
- Nrf2 mRNA directly correlated with eGFR in patients with DKD
- r=0.34, p=0.05
- In mediation analysis, eGFR was the first-ranked factor explaining the difference in Nrf2 mRNA between patients with and without DKD
Original publication
Role of kidney function on Nrf2 mRNA levels in type 2 diabetes. BMJ Open Diabetes Res Care. Published 3 April 2024. doi:10.
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