Vitamin D Status, Vitamin D Receptor Polymorphisms, and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes: A Prospective Study
Main finding · Composite diabetic microvascular complicationsResult — go to the resultMultivariable-adjusted HR 0.65 95% CI 0.51–0.84Authors' conclusion
Higher serum 25(OH)D concentrations were significantly associated with lower risk of diabetic microvascular complications, including diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy. Our findings suggest a potential beneficial role of maintaining adequate vitamin D status in the prevention of diabetic microvascular complications.
Study context
- Population
- Participants with T2D free of microvascular complications, UK Biobank1,370 events
- Participants
- 14,709 participants
- Exposure
- Serum 25D ≥75 nmol/L vs <25 nmol/L
- Outcome
- Incident diabetic microvascular complications (composite), ascertained via electronic health records
- Follow-up
- Median 11.2 years
Methodological detailsUK Biobank, multivariable-adjusted Cox proportional hazards models
- UK Biobank
- Multivariable-adjusted Cox proportional hazards models
Main finding
Composite diabetic microvascular complications
Multivariable-adjusted HR
0.65
95% CI 0.51–0.84
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Multivariable-adjusted HR (CI) | |
|---|---|---|
| Diabetic retinopathy | 0.62 (0.40–0.95) | |
| Diabetic nephropathy | 0.56 (0.40–0.79) | |
| Diabetic neuropathy | 0.48 (0.26–0.89) | |
| Composite microvascular complications by 25(OH)D and VDR genotype (rs1544410, rs731236)25(OH)D ≥50 nmol/L and CC of rs1544410vs 25(OH)D <25 nmol/L and TT of rs1544410 | 0.54 (0.38–0.78) | |
| Composite microvascular complications by 25(OH)D and VDR genotype (rs1544410, rs731236)25(OH)D ≥50 nmol/L and AA of rs731236vs 25(OH)D <25 nmol/L and GG of rs731236 | 0.55 (0.38–0.80) | |
| 0.20.5125Multivariable-adjusted HR (log scale) |
Composite microvascular complications by 25(OH)D and vitamin D receptor (VDR) genotype (rs1544410, rs731236)
- No significant interaction observed
Serum 25(OH)D concentration (all participants) · baseline
- Median serum 25(OH)D 40.7 nmol/L (IQR 27.5, 56.4)
Original publication
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