Metabolic status modifies skeletal response to active vitamin D: a post hoc analysis of the Diabetes Prevention with Vitamin D (DPVD) randomized trial
Authors' conclusion
These findings suggest that metabolic status influences skeletal response to active vitamin D therapy and support the concept of bone-metabolic coupling.
Study context
- Population
- Individuals with prediabetes with longitudinal bone mineral density (BMD) measurements; glycemic trajectory: incident T2D, persistent prediabetes or regression to normoglycemiaof 1,256 with prediabetes
- Participants
- 1,164 individuals
- Comparison
- Eldecalcitol vs placebo, by glycemic trajectory
- Primary endpoint
- Change in lumbar spine BMD
- Follow-up
- 3 years
Methodological detailspost hoc, placebo-controlled, linear mixed-effects model
- Post hoc
- Placebo-controlled
- Linear mixed-effects model
Primary result
As reported in the abstract
Lumbar spine BMD increase in eldecalcitol by glycemic trajectory
Eldecalcitol vs Placebo: treatment-by-trajectory-by-time interaction, P=0.0307 · Eldecalcitol vs Placebo: trajectory-by-time interaction, P=0.0098 · Placebo: P = 0.772
Further findings
| Outcome | β (percentage points) (95% CI) | P value |
|---|---|---|
| Baseline factors associated with 3-year % change in lumbar spine BMD (multivariable linear regression) · analysed in the eldecalcitol group | −5.15 (−8.34 to −1.95) | P = 0.002 |
Baseline factors associated with 3-year % change in lumbar spine BMD (multivariable linear regression)
- Lower baseline HbA1c independently associated with greater 3-year increase in lumbar spine BMD
Original publication
Metabolic status modifies skeletal response to active vitamin D: a post hoc analysis of the Diabetes Prevention with Vitamin D (DPVD) randomized trial. J Clin Endocrinol Metab. Published 29 September 2026. doi:10.
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