Economic evaluation of NT-proBNP testing plus standard clinical assessment versus standard clinical assessment alone for the prevention of heart failure in older adults with type 2 diabetes
Authors' conclusion
Annual NT-proBNP testing in older adults with type 2 diabetes is cost-effective for early HF detection in a Medicare setting
Study context
- Population
- Adults aged ≥65 years with T2D, with or without other heart failure (HF) risk factors; model inputs from published literature and Medicare data
- Comparison
- NT-proBNP testing plus standard clinical assessment vs standard clinical assessment alone
- Outcome
- Direct medical costs, life-years (LYs) and quality-adjusted life-years (QALYs)
- Follow-up
- Lifetime horizon
Methodological detailsMarkov model with embedded decision tree, five-state Markov model, lifetime horizon, Medicare perspective, sensitivity and scenario analyses
- Markov model with embedded decision tree
- Five-state Markov model
- Lifetime horizon
- Medicare perspective
- Sensitivity and scenario analyses
Main finding
As reported in the abstract
Cost-effectiveness: QALYs over a lifetime horizon (Medicare perspective)
- NT-proBNP was cost-effective: incremental cost per QALY gained
- US$40 883
Further findings
Survival (LYs) · lifetime
Lifetime costs
| Outcome | NT-proBNP testing | Standard clinical assessment |
|---|---|---|
| Lifetime HF hospitalizations | 0.43 | 0.43 |
| LY-adjusted HF hospitalizations · lifetime | 0.29 | 0.43 |
- Lifetime costs: reflecting longer survival and greater use of cardioprotective treatments
Sensitivity analyses
- Results robust; most sensitive to diabetes management costs, mortality among high-risk individuals and cardioprotective drug effectiveness
Original publication
Economic evaluation of NT-proBNP testing plus standard clinical assessment versus standard clinical assessment alone for the prevention of heart failure in older adults with type 2 diabetes. BMJ Open Diabetes Res Care. Published 28 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →