The effect of starting metformin on bone mineral density among women with type 2 diabetes in the Study of Women’s Health Across the Nation (SWAN)
Authors' conclusion
Women in the mid-life starting metformin had longitudinal changes in BMD very similar to other women not starting metformin.
Study context
- Population
- Mid-life women with T2D in SWAN, a diverse community-based US cohort, with bone mineral density (BMD) measurements; mean age 57.4 years, 35.9% Whitematched cohort
- Participants
- 248 women
- Exposure
- Metformin initiators vs noninitiators
- Metformin initiatorsn = 124
- Noninitiatorsn = 124reference
- Outcome
- Longitudinal change in BMD
- Follow-up
- median 3-year follow-up
Methodological detailsSWAN, propensity score matching, community-based US cohort
- SWAN
- Propensity score matching
- Community-based US cohort
Main finding
As reported in the abstract
BMD loss at all anatomic areas
- BMD loss at all anatomic areas similar between metformin initiators and nonusers
- Metformin initiators vs Noninitiators: all p > 0.3
- Propensity score matched
Observational data: associations, not effects.
Further findings
Subgroup analyses incl. baseline fasting blood glucose
- No between-group differences in subgroups
Original publication
The effect of starting metformin on bone mineral density among women with type 2 diabetes in the Study of Women’s Health Across the Nation (SWAN). Osteoporos Int. Published 21 September 2023. doi:10.
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