Persistence or regression of prediabetes and coronary artery calcification among adults without diabetes
Authors' conclusion
Unfavorable changes in glycemic status, including persistence of prediabetes or progression to diabetes from prediabetes, were associated with increased risk of CAC.
Study context
- Population
- Adults without diabetes; glycemic status changes over 1.5 years (IQR 1.0–2.0) before first coronary artery calcium score (CACS) assessment; mean (SD) age 41.3 (7.0) years, 74.7% male40,622 in longitudinal sub-study
- Participants
- 126,765 adults
- Comparison
- Changes in glycemic status vs persistent normoglycemia
- Primary endpoint
- Prevalent coronary artery calcification (CAC)
Methodological detailslogistic regression, mixed models with random intercepts and random slopes, multivariable-adjusted
- Logistic regression
- Mixed models with random intercepts and random slopes
- Multivariable-adjusted
Primary result
As reported in the abstract
Prevalent CAC (multivariable-adjusted OR)
Each group vs persistent normoglycemiaOdds ratio (95% CI)
Persistent prediabetes
1.13(1.08–1.18)
Prediabetes to normoglycemia
1.05(0.98–1.12)
Prediabetes to diabetes
1.46(1.27–1.67)
Further findings
| Outcome | Ratio of 5-year CAC progression rates (95% CI) |
|---|---|
| 5-year CAC progression rate (multivariable-adjusted ratio) · 5 yearsPersistent prediabetes vs Persistent normoglycemia · multivariable-adjusted · longitudinal sub-study | 1.19 (1.16–1.22) |
| 5-year CAC progression rate (multivariable-adjusted ratio) · 5 yearsPrediabetes to normoglycemia vs Persistent normoglycemia · multivariable-adjusted · longitudinal sub-study | 1.11 (1.07–1.14) |
| 5-year CAC progression rate (multivariable-adjusted ratio) · 5 yearsPrediabetes to diabetes vs Persistent normoglycemia · multivariable-adjusted · longitudinal sub-study | 1.63 (1.26–2.10) |
5-year coronary artery calcification (CAC) progression rate (multivariable-adjusted ratio)
- CAC progression increased significantly in all prediabetes groups
Original publication
Persistence or regression of prediabetes and coronary artery calcification among adults without diabetes. Eur J Endocrinol. Published 10 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →