High‐protein vegan and omnivorous diets improve peripheral insulin sensitivity to a similar extent in people with type 2 diabetes
Authors' conclusion
High-protein diets, whether predicated on vegan or omnivorous proteins, can improve glycaemic control by increasing peripheral insulin sensitivity in people with T2D.
Study context
- Population
- Adults with T2D (f = 5, age 58.3 ± 8.3 years, BMI 32.9 ± 4.7 kg∙m-2, HbA1c 60 ± 15 mmol∙mol-1); 5-week eucaloric high-protein (30% energy from protein) diet
- Participants
- 17 adults
- Comparison
- Mycoprotein-rich high-protein vegan diet vs isonitrogenous high-protein omnivorous diet
Primary result
As reported in the abstract
Peripheral insulin sensitivity: increase in RdT/Insulin (two-step hyperinsulinaemic-euglycaemic clamp (HEC)) · 5 weeks
- Intervention effect on peripheral insulin sensitivity
- P = 0.006
Further findings
Glycaemic variability: increase in time in range (CGM)
- Glycaemic variability: increase in time in range (CGM) — Intervention effect on glycaemic variability
- p = 0.040
HbA1c
- Improved in both groups; intervention effect
- P = 0.001
Hepatic insulin sensitivity; postprandial blood glucose and serum C-peptide during mixed-meal tolerance test (MMTT)
- No improvements
- P > 0.05
Original publication
High‐protein vegan and omnivorous diets improve peripheral insulin sensitivity to a similar extent in people with type 2 diabetes. Diabetes Obes Metab. Published 27 November 2024. doi:10.
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