Early time-restricted carbohydrate consumption vs conventional dieting in type 2 diabetes: a randomised controlled trial
Authors' conclusion
The proposed eTRC diet provides a feasible and effective alternative option for glucose and body weight management in individuals with type 2 diabetes, with no additional metabolic benefits compared with conventional dieting.
Study context
- Population
- Adults with T2D and overweight/obesity (age 67.2±7.9 years, 47.8% women, BMI 29.4±3.7 kg/m², HbA1c 49±5 mmol/mol [6.6±0.5%]), free-living conditions12 eTRC, 11 control completed
- Comparison
- 12 week eTRC diet vs Mediterranean-style control diet with matched energy restriction and macronutrient distribution
- Primary endpoint
- Between-group difference in HbA1c
- Follow-up
- 12 weeks
Methodological detailsparallel-arm, open label
- Parallel-arm
- Open label
Primary result
As reported in the abstract
HbA1c change
| Group | Value | Change in % |
|---|---|---|
| eTRC | −3 (interval −6–-0.3) mmol/mol | −0.2 [−0.5, 0]% |
| Control | −4 (interval −6–-2) mmol/mol | −0.3 [−0.5, −0.1]% |
Value
eTRC−3 (interval −6–-0.3) mmol/mol
Control−4 (interval −6–-2) mmol/mol
Change in %
eTRC−0.2 [−0.5, 0]%
Control−0.3 [−0.5, −0.1]%
- eTRC vs Control: P = 0.386 — comparable improvements
Further findings
Completion
Body weight, fat mass and glucometabolic variables
- Similar reductions in body weight and fat mass
- Comparable improvements in FPG, flash glucose monitoring-derived glucose variability, MMTT-derived glucose tolerance, insulin resistance, insulin clearance and plasma glucagon
- No changes in model-derived beta cell function, GLP-1, GIP and non-esterified fatty acids
- Both diets similarly reduced liver function markers and TG
- Exploratory: diet-induced changes not related to timing of carbohydrate intake
Safety
- Both diets neutral on other cardiometabolic and safety variables
Original publication
Early time-restricted carbohydrate consumption vs conventional dieting in type 2 diabetes: a randomised controlled trial. Diabetologia. Published 16 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →