Safety and efficacy of intermittent fasting with or without exercise in people living with overweight or obesity and type 2 diabetes—The INTERFAST ‐3 study design
Study context
- Population
- People with T2D, BMI >27 kg/m², HbA1c ≥53 mmol/mol (≥7.0%) and ≤86 mmol/mol (≤10.0%), without insulin therapy
- Planned comparison
- Intermittent energy restriction, exercise or their combination vs control
- Primary endpoint
- Change in body weight from baseline
- Follow-up
- Day 84
Methodological detailsmonocentric, parallel-group, Equal random allocation to four groups, 12-week intervention phase, followed by a two-year follow-up phase, Also measured: glycaemic parameters, resting energy expenditure (REE), body composition, OGTT at baseline and end of intervention, stool microbiome, individual-related outcomes, continuous glucose monitoring (CGM) in all participants
- Monocentric
- Parallel-group
- Equal random allocation to four groups
- 12-week intervention phase, followed by a two-year follow-up phase
- Also measured: glycaemic parameters, REE, body composition, OGTT at baseline and end of intervention, stool microbiome, individual-related outcomes, CGM in all participants
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Safety and efficacy of intermittent fasting with or without exercise in people living with overweight or obesity and type 2 diabetes—The INTERFAST ‐3 study design. Diabet Med. Published 15 April 2026. doi:10.
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