Effect of 5:2 Regimens: Energy-Restricted Diet or Low-Volume High-Intensity Interval Training Combined With Resistance Exercise on Glycemic Control and Cardiometabolic Health in Adults With Overweight/Obesity and Type 2 Diabetes: A Three-Arm Randomized Controlled Trial
Authors' conclusion
These findings suggest that the medically supervised 5:2 energy-restricted diet could provide an alternative strategy for improving glycemic control and that the exercise regimen could improve body composition, although it inadequately improved glycemic control.
Study context
- Population
- Adults with overweight/obesity and T2D
- Participants
- 326 adults
- Comparison
- 5:2 energy-restricted diet or HIIT plus resistance exercise vs routine lifestyle education
- Dietn = 109
- Exercisen = 108
- Controln = 109reference
- Primary endpoint
- Change in HbA1c, diet or exercise vs control
- Follow-up
- 12 weeks
Methodological detailstwo-center, open-label, three-arm, parallel-group
- Two-center
- Open-label
- Three-arm
- Parallel-group
Primary result
As reported in the abstract
Change in HbA1c (%)
Diet
−0.72
95% CI −0.95–-0.48 · %
Exercise
−0.46
95% CI −0.70–-0.23 · %
Control
−0.37
95% CI −0.60–-0.15 · %
Each group vs controlDifference, % (95% CI)P value
Diet
−0.34(−0.58 to −0.11)
P = 0.007Exercisedid not significantly differ
−0.09(−0.32 to 0.15)
P = 0.47Further findings
Lean body mass
- Exercise superior in maintaining lean body mass
Adiposity and hepatic steatosis
- Both diet and exercise improved adiposity and hepatic steatosis
Original publication
Effect of 5:2 Regimens: Energy-Restricted Diet or Low-Volume High-Intensity Interval Training Combined With Resistance Exercise on Glycemic Control and Cardiometabolic Health in Adults With Overweight/Obesity and Type 2 Diabetes: A Three-Arm Randomized Controlled Trial. Diabetes Care. Published 18 April 2024. doi:10.
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