Identification of diagnostic biomarkers used in the diagnosis of cardiovascular diseases and diabetes mellitus: A systematic review of quantitative studies
Authors' conclusion
While advanced analytical techniques are expensive, laboratories in LMICs should carry out a cost-benefit analysis of their use. Alternatively, laboratories may want to explore emerging techniques such as infrared, Fourier transform-infrared and near-infrared spectroscopy, which allow sensitive noninvasive analysis.
Study context
- Population
- Studies identifying diagnostic biomarkers for cardiovascular diseases (CVDs) and diabetes mellitus (DM), for potential use in low- and middle-income countries (LMICs)18 studies
- Outcome
- Diagnostic biomarkers for CVD and DM
Methodological detailssix databases, January 2002–January 2023, three reviewers
- Six databases
- January 2002–January 2023
- Three reviewers
Pooled result
As reported in the abstract
Diagnostic biomarkers identified
234
Biomarkers for CVD
74
Biomarkers for DM
160
Further pooled results
Analytical techniques
- Liquid chromatography mass spectrometry, ELISA and vibrational spectroscopy repeatedly reported, used with traditional and alternative matrices (fingernails, hair, saliva)
Original publication
Identification of diagnostic biomarkers used in the diagnosis of cardiovascular diseases and diabetes mellitus: A systematic review of quantitative studies. Diabetes Obes Metab. Published 18 April 2024. doi:10.
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