Associations between prior wasting malnutrition and indices of insulin secretion and sensitivity among six cohorts from Asia and Africa: The SAMPA study
Authors' conclusion
PM affects glucose metabolism differently according to current BMI. Remaining underweight is associated with low insulin secretion and weight gain following PM is linked to reduced insulin sensitivity.
Study context
- Population
- Children and adults from cohorts in Zambia, Tanzania, India and the Philippines (low- and middle-income countries (LMICs))analysed
- Participants
- 2,172 children
- Exposure
- Prior wasting malnutrition vs no prior wasting malnutrition
- Outcome
- Insulin sensitivity and secretion indices (HOMA2 %S, HOMA2 %B, Matsuda index, insulinogenic index, disposition index) from an OGTT
Methodological detailssix cohorts, adjusted linear regression
- Six cohorts
- Adjusted linear regression
Main finding
As reported in the abstract
Insulin indices, PM vs NPM
Children: Matsuda index lower in PM vs NPM
20%-24%
Adults with PM in early life (36-37 years before), adjusted for current body mass index (BMI): Matsuda index lower in PM vs NPM
18%
Adults with more recent PM (3-17 years previously): HOMA2 %B lower in PM vs NPM
10%-20%
Adults with more recent PM (3-17 years previously): Matsuda index higher in PM vs NPM
21%-47%
Observational data: associations, not effects.
Further findings
- Those with PM had lower current BMI
Original publication
Associations between prior wasting malnutrition and indices of insulin secretion and sensitivity among six cohorts from Asia and Africa: The SAMPA study. Diabet Med. Published 16 September 2026. doi:10.
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