Genetic Underpinnings of Fasting and Oral Glucose-stimulated Based Insulin Sensitivity Indices
Study context
- Population
- Family cohort for heritability and correlations; population cohort Inter99 for associations with 426 T2D-associated genetic variants2 cohorts · Family cohort 313 · population cohort Inter99 5,343
- Exposure
- Genetic components of fasting vs oral glucose tolerance test (OGTT)-based insulin sensitivity (IS) indices
- Outcome
- Heritability, genetic/phenotypic correlations and T2D-variant associations of 21 IS indices
Methodological detailsfamily cohort, population cohort (Inter99)
- Family cohort
- Population cohort (Inter99)
Main finding
As reported in the abstract
Heritability of IS indices
19% to 38%
Fasting and highly correlated OGTT-based indices: pairwise genetic and phenotypic correlations
0.88 to 1
Wide-correlation OGTT-based indices: pairwise genetic correlations
0.17-1.00
Wide-correlation OGTT-based indices: pairwise phenotypic correlations
0.13-0.97
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Genetic Underpinnings of Fasting and Oral Glucose-stimulated Based Insulin Sensitivity Indices. J Clin Endocrinol Metab. Published 18 April 2024. doi:10.
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