Estimation of Glucose Absorption, Insulin Sensitivity, and Glucose Effectiveness From the Oral Glucose Tolerance Test
Authors' conclusion
Our novel model SI has a good correlation with SI from the widely used Dalla Man's model while concurrently calculating GE and GIGt1/2. Thus, besides estimating SI, our novel model can quantify differences in insulin-independent glucose disposal mechanisms important for diabetes pathophysiology.
Study context
- Population
- Subjects without oral glucose tolerance test (OGTT) abnormalities and subjects with diabetes undergoing a 75-gram 120-minute 6-timepoint OGTT at an academic medical center
- Participants
- 88 vs 17
- Exposure
- Novel OGTT model vs Dalla Man OGTT model; diabetes vs controls
- Diabetesn = 88
- Controlsn = 17reference
- Outcome
- Agreement of SI from the novel model with SI from the Dalla Man model (Bland-Altman limits of agreement)
Methodological detailssingle academic medical center
- Single academic medical center
Main finding
As reported in the abstract
| Group | ƿ | P |
|---|---|---|
| Controls | 0.90 | P < .001 |
| Diabetes | 0.77 | P < .001 |
ƿ
Controls0.90
Diabetes0.77
P
ControlsP < .001
DiabetesP < .001
Observational data: associations, not effects.
Further findings
Glucose effectiveness (GE) · higher in diabetes
P = 0.02
Gastrointestinal glucose half-life (GIGt1/2)
Gastrointestinal glucose half-life (GIGt1/2)
- Shorter in diabetes than controls, without statistical difference
Original publication
Estimation of Glucose Absorption, Insulin Sensitivity, and Glucose Effectiveness From the Oral Glucose Tolerance Test. J Clin Endocrinol Metab. Published 13 May 2024. doi:10.
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