Interactions of genes with alcohol consumption affect insulin sensitivity and beta cell function
Authors' conclusion
Our findings reveal the effects of the interaction of alcohol and rs56221195 on hepatic insulin sensitivity in NGT individuals. It is imperative to weigh potential benefits and detriments thoughtfully when considering alcohol consumption across diverse genetic backgrounds.
Study context
- Population
- Individuals with normal glucose tolerance (OGTT-confirmed), Nanjing and Jurong, China; T2D risk evaluated in UK Biobank1,862 normal glucose tolerance (NGT) discovery
- Comparison
- Alcohol consumption categories by rs56221195 genotype
- Outcome
- Genetic variants modulating the impact of alcohol consumption on insulin sensitivity and beta cell function
Methodological detailsdiscovery and validation cohorts, exploratory genome-wide association study, UK Biobank Cox proportional hazard regression
- Discovery and validation cohorts
- Exploratory genome-wide association study
- UK Biobank Cox proportional hazard regression
Performance
As reported in the abstract
rs56221195 × alcohol interaction on liver insulin resistance index (LIRI)
- Interaction of rs56221195 with alcohol intake on liver insulin resistance index (LIRI), discovery corroborated in validation set (combined p)
- p=1.32 × 10-11
Further findings
rs56221195 × alcohol interaction on total insulin secretion index INSR120
- Significant interaction on INSR120, but not on disposition index
- P = 2.06 × 10-9
rs56221195 × alcohol interaction and T2D risk (UK Biobank)
- HR for T2D linked to rs56221195 × alcohol interaction
- HR 0.897, p=0.008
Drinking level and insulin sensitivity, resistance and secretion in NGT
- Drinking levels significantly correlated with insulin sensitivity, with inverse relationship with insulin resistance and beta cell insulin secretion (adjusted); no significant associations in disposition indexes
Original publication
Interactions of genes with alcohol consumption affect insulin sensitivity and beta cell function. Diabetologia. Published 19 October 2024. doi:10.
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