Effect of weight-maintaining ketogenic diet on glycemic control and insulin sensitivity in obese T2D subjects
Authors' conclusion
In the absence of weight loss, a low carbohydrate ketogenic diet has no beneficial effect on glucose tolerance, insulin sensitivity, or other metabolic parameters.
Study context
- Population
- Overweight obese subjects with T2D3 diets · 10 days
- Participants
- 29 subjects
- Comparison
- Weight-maintaining ketogenic diet vs weight-maintaining standard diet
Primary result
As reported in the abstract
10 days
- Glucose tolerance decreased slightly or remained unchanged in the two ketogenic diet groups
- Whole body (muscle), liver and adipose tissue insulin sensitivity unchanged in all 3 groups
Further findings
Body weight, fat content, % body fat (DEXA) · 10 days
- Remained constant in all three groups
Substrate metabolism with ketogenic diet
- Plasma β-OH-B concentration increased twofold
- Carbohydrate oxidation decreased and lipid oxidation increased
Plasma lipid profile and blood pressure
- Unchanged in all 3 groups
Original publication
Effect of weight-maintaining ketogenic diet on glycemic control and insulin sensitivity in obese T2D subjects. BMJ Open Diabetes Res Care. Published 18 October 2024. doi:10.
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