Glucose Metabolic Abnormalities and Their Interaction With Defective Phosphate Homeostasis in Tumor-induced Osteomalacia
Authors' conclusion
The development of diabetes in TIO patients may be predisposed by ambulatory issues, low phosphate, and elevated FGF23 levels. Dysglycemia might further aggravate hypophosphatemia.
Study context
- Population
- Patients with tumor-induced osteomalacia, individuals with normal glucose tolerance and patients with T2D, undergoing oral glucose tolerance test (OGTT) with serum phosphate and FGF23 monitored
- Participants
- 20 / 20 / 20
- Exposure
- Tumor-induced osteomalacia (TIO) patients vs individuals with normal glucose tolerance vs patients with T2D
- TIOn = 20
- Normal glucose tolerancen = 20reference
- Type 2 diabetes mellitus (DM)n = 20
- Outcome
- Glucose metabolic profile in TIO
Main finding
As reported in the abstract
TIO patients with impaired glucose tolerance (IGT)
60%
12/20
TIO patients with T2D
5%
1/20
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| TIO with IGT or T2D vs TIO without these conditionsIGT or T2D vs Without IGT or T2D · Phosphate lower with IGT or T2D: 0.43 ± 0.10 vs 0.53 ± 0.10 | P = 0.042 |
| TIO with IGT or T2D vs TIO without these conditionsIGT or T2D vs Without IGT or T2D · Calcium lower with IGT or T2D: 2.20 ± 0.08 vs 2.30 ± 0.40 | P = 0.001 |
| Glucose at 60 min by FGF23 level in TIO · 60 minutesHigh FGF23 vs Low FGF23 · Higher with high FGF23: 10.5 [9.3, 12.3] vs 7.3 [6.4, 10.1] | P = 0.048 |
- TIO with IGT or T2D vs TIO without these conditions — More ambulatory difficulties with IGT or T2D
- 69.2% vs 42.9%
Correlation of serum phosphate with glucose metabolism in TIO
- Serum phosphate negatively correlated with plasma glucose at 60 min
- P < 0.001
- Serum phosphate negatively correlated with fasting plasma insulin
- P < 0.05
- Serum phosphate negatively correlated with HOMA-IR
- P < 0.05
FGF23 and phosphate after glucose loading
- Both FGF23 and phosphate levels exhibited a decreasing trend after glucose loading
Original publication
Glucose Metabolic Abnormalities and Their Interaction With Defective Phosphate Homeostasis in Tumor-induced Osteomalacia. J Clin Endocrinol Metab. Published 28 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →