Mean platelet volume (MPV) as new marker of diabetic macrovascular complications in patients with different glucose homeostasis : Platelets in cardiovascular risk
Authors' conclusion
In the present study we highlighted that MPV is significantly increased, not only in newly diagnosed T2DM patients, but also in early stage of diabetes, indicating that subjects with pre-diabetes present increased platelets reactivity. Moreover, our results suggest that MPV is associated with increased arterial stiffness and subclinical myocardial damage, indicating MPV as new marker of CV risk.
Study context
- Population
- Newly diagnosed hypertensive patients, classified by Oral Glucose Tolerance test (OGTT)
- Participants
- 400 participants
- Exposure
- NGT vs pre-diabetes vs newly diagnosed T2D
- Outcome
- MPV values and their correlation with arterial stiffness and subclinical myocardial damage
Methodological detailsArterial stiffness by carotid-femoral pulse wave velocity (PWV), augmentation pressure and augmentation index; echocardiography
- Arterial stiffness by carotid-femoral PWV, augmentation pressure and augmentation index; echocardiography
Main finding
As reported in the abstract
MPV
- MPV rose from the NGT group to the T2DM group
- MPV correlated positively with arterial stiffness and subclinical myocardial damage parameters
- T2DM vs NGT: P < 0.0001
Observational data: associations, not effects.
Further findings
Fasting plasma glucose (FPG), fasting plasma insulin, high sensitivity c reactive protein (hs-CRP) and eGFR across groups
- Increase in FPG among groups
- P < 0.0001
- Increase in fasting plasma insulin among groups
- P < 0.0001
- Increase in hs-CRP among groups
- P < 0.0001
- Decrease in eGFR among groups
- P < 0.0001
Original publication
Mean platelet volume (MPV) as new marker of diabetic macrovascular complications in patients with different glucose homeostasis : Platelets in cardiovascular risk. Cardiovasc Diabetol. Published 2 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →