Combined exposure to multiple air pollutants and incident ischemic heart disease in individuals with and without type 2 diabetes: A cohort study from the UK Biobank
Authors' conclusion
The combined exposure to multiple air pollutants has been associated with an elevated risk of incident IHD, and the association is more pronounced among individuals with T2D.
Study context
- Population
- Individuals free of CVD and cancer from the UK Biobank, with and without T2D20,036 with T2D
- Participants
- 388,780 individuals
- Exposure
- Highest vs lowest tertile of weighted air pollution score, by T2D status
- Outcome
- Incident ischemic heart disease (IHD)
- Follow-up
- Median 12.9 years
Methodological detailsUK Biobank, multivariable-adjusted Cox proportional hazard models
- UK Biobank
- Multivariable-adjusted Cox proportional hazard models
Main finding
As reported in the abstract
Incident IHD
Highest APS tertile vs Lowest APS tertileAdjusted hazard ratio (95 % CI)
With T2D
1.13(1.03–1.23)
Without T2D
1.06(1.03–1.10)
- Incident ischemic heart disease (IHD) cases
- 27333
Observational data: associations, not effects.
Further findings
Dose-response of air pollution score (APS) with IHD
- Linear relationship with T2D (nonlinearity: P = 0.37)
- Non-linear relationship without T2D (nonlinearity: P = 0.02)
Joint analysis: highest APS tertile with T2D vs lowest APS tertile without T2D
- Higher risk of IHD
- 54 %
- Significant additive interaction
- P for interaction < 0.01
- Proportion of relative excess risk due to interaction
- 17 %
Original publication
Combined exposure to multiple air pollutants and incident ischemic heart disease in individuals with and without type 2 diabetes: A cohort study from the UK Biobank. Diabetes Res Clin Pract. Published 15 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →