Signs of Glucagon Resistance After a 2-Week Hypercaloric Diet Intervention
Authors' conclusion
Our results indicate that short-term unhealthy behavior, which increases hepatic fat content, causes a reversible resistance to the effect of glucagon on amino acid concentrations in healthy individuals, which may explain the hyperglucagonemia associated with obesity and diabetes.
Study context
- Population
- Healthy male individuals
- Participants
- 20 healthy males
- Comparison
- After 2-week hypercaloric diet and sedentary lifestyle vs baseline
- Outcome
- Amino acid response to glucagon infusion during pancreatic clamp (somatostatin, basal insulin)
- Follow-up
- After 2-week intervention vs baseline
Methodological detailssingle-group, pre-post, 8-week follow-up
- Single-group
- Pre-post
- 8-week follow-up
Main finding
As reported in the abstract
- Glucagon infusion decreased total amino acids on all experimental days
- After intervention vs Baseline: P = 0.015
- After intervention vs Baseline: P = 0.016
Further findings
Hepatic fat content (MR spectroscopy) · after 2-week intervention
- Increase in hepatic fat content
- 382% [206%; 705%], P < .01
Reversibility · 8 weeks after intervention
- Changes normalized at follow-up
Original publication
Signs of Glucagon Resistance After a 2-Week Hypercaloric Diet Intervention. J Clin Endocrinol Metab. Published 15 November 2023. doi:10.
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