Circulating tumor necrosis factor-related biomarkers predict kidney function decline in Japanese patients with diabetes: An observational cohort study
Authors' conclusion
Elevated TNFR1, TNFR2, and EphA2 were associated with both kidney and composite outcomes in Japanese patients with diabetes.
Study context
- Population
- Japanese patients with diabetes
- Participants
- 640 patients
- Exposure
- Per-SD increase in log-transformed circulating tumor necrosis factor (TNF)-related biomarkers
- Outcome
- Kidney outcome: 30% reduction in eGFR from baseline; composite outcome: kidney outcome plus death before kidney outcome
- Follow-up
- Median 5.4 years
Main finding
As reported in the abstract
Kidney outcome (30% eGFR reduction)
Reached kidney outcome
75
11.7%
Observational data: associations, not effects.
Further findings
Composite outcome (kidney outcome plus death before kidney outcome) · median follow-up 5.4 years
- Died before reaching kidney outcome
- 37 (5.8%)
- Circulating osteoprotegerin associated with composite outcome only
Original publication
Circulating tumor necrosis factor-related biomarkers predict kidney function decline in Japanese patients with diabetes: An observational cohort study. Diabetes Res Clin Pract. Published 14 November 2023. doi:10.
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