Weight Loss Improves Predicted 10‐Year Major Adverse Cardiovascular Events (MACE) and Type 2 Diabetes Risk, but Benefits Partially Rebound at 1 Year
Authors' conclusion
Weight loss reduced MACE and T2D risks, but both rebounded with weight regain.
Study context
- Population
- Sedentary women with overweight (21–49 years); 115 African American115 African American
- Participants
- 221 women
- Comparison
- Diet+Aerobic vs Diet+Resistance vs Diet-only
- Primary endpoint
- Changes in predicted 10-year risk for MACE and T2D (cardiometabolic disease staging equations)
- Follow-up
- Baseline, post-weight loss and 1-year follow-up
Primary result
As reported in the abstract
Baseline to Post-WL to 1 year
- MACE risk decreased from Baseline to post-weight loss (Post-WL) and rebounded from Post-WL to 1 year in all groups
- all p < 0.001
- T2D risk decreased in all groups but rebounded in Diet+Aerobic and Diet-only
- all p < 0.001
- Diet+Resistance maintained a significant net T2D risk reduction at 1 year
- p = 0.003
Further findings
BMI · Baseline, Post-WL, 1 year
- Mean BMI decreased from 28.3 to 23.9 kg m-2, with regain to 25.8 at 1 year
Follow-up exercise adherence and T2D risk rebound · 1 year
- Follow-up exercise adherence associated with lower T2D risk rebound
- P = 0.024
Original publication
Weight Loss Improves Predicted 10‐Year MACE and Type 2 Diabetes Risk, but Benefits Partially Rebound at 1 Year. Obesity (Silver Spring). Published 23 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →