Weight loss maintenance with exercise and liraglutide improves glucose tolerance, glucagon response, and beta cell function
Authors' conclusion
Only the combination of exercise and liraglutide improved glucose tolerance, beta cell function, and glucagon responses after weight loss.
Study context
- Population
- Adults with obesity (BMI 32–43 kg/m²) without diabetes after an 8-week low-calorie diet (800 kcal/d)randomized
- Participants
- 195 adults
- Comparison
- Exercise, liraglutide 3.0 mg/d, or both combined vs placebo for 52 weeks after diet-induced weight loss
- Primary endpoint
- Change in glucose and glucagon response to a 3-hour mixed meal test and disposition index (beta cell function)
- Follow-up
- 1 year
Methodological detailsplacebo-controlled
- Placebo-controlled
Primary result
As reported in the abstract
Postprandial glucose response, beta cell function and glucagon response
Each group vs placeboEstimate (95% CI)P value
Combination
change in postprandial glucose response −9%(−14% to −3%)
P = 0.002Combination
change in glucagon response −18%(−34% to −3%)
P = 0.024Liraglutide
change in postprandial glucose response −7%(−12% to −1%)
P = 0.018- Combination · improved
- change in beta cell function 49% (95% CI 16%–93%); P = 0.002
Original publication
Weight loss maintenance with exercise and liraglutide improves glucose tolerance, glucagon response, and beta cell function. Obesity (Silver Spring). Published 21 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →