Weight Loss Induces Changes in Vitamin D Status in Women With Obesity But Not in Men: A Randomized Clinical Trial
Authors' conclusion
Weight loss induced by a low-calorie diet resulted in an increase in serum 25(OH)D in both women and men. Only in women, further weight loss had an additional beneficial impact on vitamin D. Additionally, initial low serum 25(OH)D was associated with successful weight loss maintenance in women but not men.
Study context
- Population
- Individuals with obesity (BMI 32–43 kg/m²) after an 8-week low-calorie diet-induced weight loss, then 52 weeks of liraglutide, exercise, both combined or placebo for weight loss maintenance
- Participants
- 195 individuals
- Comparison
- Change in serum 25D with weight loss, women vs men
- Primary endpoint
- Effect of weight loss on vitamin D status (serum 25(OH)D)
Primary result
As reported in the abstract
Increase in serum 25(OH)D after low-calorie diet-induced weight loss · 8 weeks
- Increase in serum 25(OH)D in both women and men
- P < 0.001 for both
Further findings
| Outcome | Increase in serum 25(OH)D (nmol/L) (95% CI) | P value | |
|---|---|---|---|
| Serum 25(OH)D change during 52-week intervention, women with further weight lossvs women regaining weight | 14 (6–22) | P = 0.001 | |
| −100102030Difference, nmol/L (linear scale) |
Baseline serum 25(OH)D, women with further weight loss at week 52 vs women regaining weight · lower with further weight loss
P < 0.001
Original publication
Weight Loss Induces Changes in Vitamin D Status in Women With Obesity But Not in Men: A Randomized Clinical Trial. J Clin Endocrinol Metab. Published 12 November 2024. doi:10.
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