One Year of Exercise After Weight Loss Increases Postprandial GLP ‐1 Secretion in Contrast to Usual Activity or GLP ‐1 Receptor Agonist Treatment
Primary result · Late-phase postprandial GLP-1 responseResult — go to the resultDifference 25% 95% CI 3%–51%Authors' conclusion
One year of exercise increased late-phase postprandial GLP-1 response, which may prevent increased appetite after weight loss and thereby weight regain.
Study context
- Population
- Adults with obesity who lost 13.1 kg on a low-calorie diet
- Participants
- 195 adults
- Comparison
- Exercise, liraglutide or combination vs usual activity after diet-induced weight loss
- Primary endpoint
- Change in late-phase GLP-1 response to a 3-h liquid mixed meal test before and after diet-induced weight loss and after 1 year of intervention
- Follow-up
- 52 weeks
Primary result
Late-phase postprandial GLP-1 response · 1 year
Difference
25%
95% CI 3%–51%
P = 0.02
Exercisevs Usual activity
difference 25% (95% CI 3%–51%); P = 0.02
As reported in the abstract
- Within-group increase with exercise
- 37% (95% CI, 20%-57%)
Further findings
Late-phase GLP-1 response after diet-induced weight loss
- Did not change
- 3% (95% CI, −4%-10%)
Original publication
One Year of Exercise After Weight Loss Increases Postprandial GLP ‐1 Secretion in Contrast to Usual Activity or GLP ‐1 Receptor Agonist Treatment. Obesity (Silver Spring). Published 25 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →