Combination of Multiple Low-Risk Lifestyle Behaviors and Incident Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies
Pooled result · Incident T2DResult — go to the resultRelative risk 0.20 95% CI 0.17–0.23Authors' conclusion
There is a very good indication that a combination of LRLBs that includes maintaining a healthy bodyweight, healthy diet, regular exercise, smoking abstinence or cessation, and light alcohol consumption is associated with a lower risk of incident type 2 diabetes.
Study context
- Population
- Prospective cohort studies reporting the association between ≥3 combined low-risk lifestyle behaviors (LRLBs) (including healthy diet) and incident T2D; databases searched up to September 202230 cohort comparisons
- Participants
- 1,693,753 participants
- Comparison
- Highest vs lowest adherence to combined low-risk lifestyle behaviors
- Outcome
- Incident T2D
Methodological detailsrandom-effects model, one-stage linear mixed model dose-response, GRADE certainty assessment
- Random-effects model
- One-stage linear mixed model dose-response
- GRADE certainty assessment
Pooled result
As reported in the abstract
Relative risk
0.20
95% CI 0.17–0.23
Highest adherencevs Lowest adherence
RR 0.20 (95% CI 0.17–0.23)
Further pooled results
Global dose-response: maximum adherence to all five LRLBs and incident T2D
- RR for maximum adherence to all five LRLBs (85% protection)
- 0.15 (95% CI 0.12-0.18)
Original publication
Combination of Multiple Low-Risk Lifestyle Behaviors and Incident Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies. Diabetes Care. Published 22 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →