Higher Prepubertal IGF-1 Concentrations Associate to Earlier Pubertal Tempo in Both Sexes
Authors' conclusion
Higher IGF-1 levels in mid-childhood are associated with earlier puberty onset. The role of IGF-1 in the onset of puberty requires further investigation.
Study context
- Population
- Boys and girls of the Growth and Obesity Chilean Cohort Study (GOCS); prepubertal IGF-1 measured at age ≈ 6.7 years; divided into 4 groups by onset age of the pubertal event
- Participants
- 1,196 participants
- Exposure
- Prepubertal IGF-1 concentration vs age at pubertal onset
- Outcome
- Age at thelarche (B2) and menarche (M) in girls and age at gonadarche (G2) in boys, by prepubertal IGF-1
Methodological detailswithin the Growth and Obesity Chilean Cohort Study (GOCS)
- Within the Growth and Obesity Chilean Cohort Study (GOCS)
Main finding
As reported in the abstract
Pubertal onset per 1 SD increase in prepubertal IGF-1
HR of B2 at younger ages per 1 SD IGF-1 (girls); maintained after adjustment for confounders
1.25
HR of M at earlier ages per 1 SD IGF-1 (girls); maintained only when adjusting for BMI, not further confounders
1.21
HR of G2 at younger ages per 1 SD IGF-1 (boys); maintained after adjustment for confounders
1.22
Observational data: associations, not effects.
Further findings
Prepubertal IGF-1 levels by age at pubertal onset
- Higher prepubertal IGF-1 at earlier ages of B2
- P = 0.003
- Higher prepubertal IGF-1 at earlier ages of M onset
- P = 0.041
- Boys: prepubertal IGF-1 tended to be higher with earlier G2 and taller height
- both p < 0.001
Prepubertal height by age at pubertal onset (girls)
- Taller prepubertal height at younger ages of B2
- P = <0.001
- Taller prepubertal height at younger ages of M
- 0.002
Original publication
Higher Prepubertal IGF-1 Concentrations Associate to Earlier Pubertal Tempo in Both Sexes. Horm Res Paediatr. Published 13 December 2022. doi:10.
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