Association between puberty timing and metabolic health at young adulthood
Main finding · MetS by pubertal timing, adjusted for BMI at puberty and maternal educationResult — go to the resultOdds ratio 0.54 95% CI 0.33–0.90Authors' conclusion
Earlier puberty is associated with adverse metabolic outcomes, but this persists after adjustment only in girls.
Study context
- Population
- Boys and girls of the Growth and Obesity Chilean Cohort Study; pubertal timing by Tanner stage (B2 in girls; G2, testicular volume >3 cc, in boys) and age at menarche; Metabolic syndrome (MetS) evaluated at age 18evaluated at age 18
- Participants
- 729 participants
- Exposure
- Earlier vs later pubertal timing
- Outcome
- MetS
- Follow-up
- 18 years
Methodological detailslongitudinal, Growth and Obesity Chilean Cohort Study
- Longitudinal
- Growth and Obesity Chilean Cohort Study
Main finding
As reported in the abstract
MetS by pubertal timing, adjusted for BMI at puberty and maternal education · age 18
Odds ratio
0.54
95% CI 0.33–0.90
Earliervs later pubertal timing (age at B2, G2 and menarche)
OR 0.54 (95% CI 0.33–0.90)
Observational data: associations, not effects.
Further findings
High TG, girls · age 18
| OR (95% CI) | ||
|---|---|---|
| Age at menarche (girls)Fully adjusted | 0.57 (0.39–0.83) | |
| 0.20.5125Odds ratio (log scale) |
High TG/glycemia ratio, girls · age 18
| OR (95% CI) | ||
|---|---|---|
| Age at menarche (girls)Fully adjusted | 0.63 (0.43–0.92) | |
| 0.512Odds ratio (log scale) |
Prevalence at age 18, boys vs girls
- MetS, boys vs girls
- 9.8% vs 4.1%
- Elevated blood pressure, boys vs girls
- 9.8% vs 0.3%
- Elevated TG, boys vs girls
- 18.1% vs 8.5%
Waist circumference and waist to height ratio, boys · age 18
- Only crude models showed inverse associations with age at G2
Original publication
Association between puberty timing and metabolic health at young adulthood. J Clin Endocrinol Metab. Published 1 April 2026. doi:10.
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