Urinary Estrogens in Girls Throughout Puberty as a Marker of Metabolic Risk and Their Relationship With Premature Adrenarche
Authors' conclusion
Our investigation suggests that metabolic risk in patients without biochemical PA are mostly associated with estrone levels. In contrast, in patients with biochemical PA, androgens are associated with MetS. Therefore, metabolic disturbances throughout puberty might be generated by different pathways in girls with and without biochemical PA.
Study context
- Population
- Girls from the Growth and Obesity Chilean Cohort Study (GOCS), followed at Tanner stage B4, 1 year (M1) and 4 years after menarche (M4)GOCS cohort
- Participants
- 321 participants
- Exposure
- Girls with vs without biochemical premature adrenarche (PA)
- Outcome
- Association of urinary estrogens with metabolic risk (MetS score)
- Follow-up
- Tanner B4, M1 and M4
Methodological detailslongitudinal, multilevel analysis
- Longitudinal
- Multilevel analysis
Main finding
As reported in the abstract
Tanner B4 to M4
- Urinary estrone correlated positively with BMI, WC, fat percentage and MetS score
- Urinary estradiol not associated with metabolic risk
- In biochemical PA, urinary estrogens not associated with metabolic score
- Multilevel analysis
Observational data: associations, not effects.
Original publication
Urinary Estrogens in Girls Throughout Puberty as a Marker of Metabolic Risk and Their Relationship With Premature Adrenarche. Clin Endocrinol (Oxf). Published 10 February 2025. doi:10.
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