Differential Methylation of CYP11B1 in Girls with High DHEAS Levels and Correlation with 11-Oxyandrogen Levels: A Pilot Study
Authors' conclusion
This pilot study proposes the hypothesis that a lower methylation of CYP11B1 may be a mechanism contributing to increased concentrations of 11-oxyandrogens in premature adrenarche and its associated metabolic risk.
Study context
- Population
- Healthy girls followed since age 3 years; methylation of CYP11B1 and HSD11B2 in peripheral blood leukocyte DNA at Tanner stage 2; 11-oxyandrogens 4 years post menarche
- Participants
- 97 participants
- Exposure
- High DHEAS vs normal DHEAS at age 6-7 years
- Outcome
- Association of circulating 11-oxyandrogen levels with methylation status of genes involved in 11-oxyandrogen steroidogenesis
Methodological detailslongitudinal cohort followed since age 3 years
- Longitudinal cohort followed since age 3 years
Main finding
As reported in the abstract
Tanner stage 2
- Significantly lower CYP11B1 methylation in High DHEAS vs Normal DHEAS
- No differences in HSD11B2 methylation
- CYP11B1 methylation correlated inversely with 11β-hydroxy-androstenedione and 11-ketotestosterone levels
Observational data: associations, not effects.
Further findings
CYP11B1 methylation vs insulin and BMI (full cohort)
- CYP11B1 methylation correlated inversely with insulin at Tanner 1 and with BMI at Tanner stage 1 and 2
Original publication
Differential Methylation of CYP11B1 in Girls with High DHEAS Levels and Correlation with 11-Oxyandrogen Levels: A Pilot Study. Horm Res Paediatr. Published 13 December 2024. doi:10.
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