Association of childhood dehydroepiandrosterone sulfate concentration, pubertal development, and DNA methylation at puberty-related genes
Authors' conclusion
The association between DHEAS and pubertal development, as reported previously, suggests a physiological connection. Our novel findings showing that DHEAS concentration correlates negatively and linearly with DNA methylation levels at regulatory regions of key puberty-related genes, provide a mechanism for such a functional relationship.
Study context
- Population
- Children in the UK birth cohort ALSPAC; blood methylome at 7.5 years, dehydroepiandrosterone sulfate (DHEAS) at 8.5 years, pubertal data 8.1–17 years
- Participants
- 91 vs 82
- Comparison
- Prepubertal DHEAS concentration vs pubertal progression and blood DNA methylation at puberty-related genes
- Boysn = 91
- Girlsn = 82
- Outcome
- DHEAS vs pubertal development and DNA methylation
Methodological detailsUK birth cohort (ALSPAC)
- UK birth cohort (ALSPAC)
Main finding
As reported in the abstract
Boys: genes near CpG islands with DHEAS-associated methylation
14
Girls: genes near CpG islands with DHEAS-associated methylation, incl. LHCGR and SRD5A2
9
Detected in both sexes
FGFR1 and FTO
Original publication
Association of childhood dehydroepiandrosterone sulfate concentration, pubertal development, and DNA methylation at puberty-related genes. Eur J Endocrinol. Published 13 December 2024. doi:10.
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