Utility of First-Morning-Voided Urinary Total Luteinizing Hormone in Detecting the Onset of Central Puberty
Authors' conclusion
A FMV total U-LH concentration of 0.6 IU/L or above reliably reflects pubertal morning S-LH levels and is effective in detecting the onset of central puberty, which occurs at similar ages in both sexes. Concurrent S-FSH or noninvasive FMV U-FSH determinations may be useful in the differential diagnosis of isolated thelarche.
Study context
- Population
- Children aged 5–15 years across Tanner stages 1 through 5
- Participants
- 297 children
- Comparison
- First-morning-voided (FMV) total urinary LH vs early morning basal serum LH ≥0.3 IU/L
- Boysn = 145
- Girlsn = 152
- Outcome
- Sensitivity and specificity of FMV total urinary LH (U-LH) for predicting early morning serum luteinizing hormone (S-LH) ≥0.3 IU/L
Methodological detailsre-analysis of previously published data set, ROC analysis
- Re-analysis of previously published data set
- ROC analysis
Performance
As reported in the abstract
FMV total U-LH predicting early morning S-LH ≥0.3 IU/L
| Test or model | Cutoff | AUC |
|---|---|---|
| Boys | 0.63 IU/L | 0.98 |
| Girls | 0.60 IU/L | 0.99 |
Cutoff
Boys0.63 IU/L
Girls0.60 IU/L
AUC
Boys0.98
Girls0.99
- Sensitivity at cutoffs 0.60 (girls) and 0.63 IU/L (boys)
- 97.4%
- Specificity at cutoffs 0.60 (girls) and 0.63 IU/L (boys)
- 90.6%
- Specificity at higher cutoffs (0.78 IU/L boys, 0.79 IU/L girls)
- 94.7%
- Sensitivity at higher cutoffs (0.78 IU/L boys, 0.79 IU/L girls)
- 94.1%
Further findings
| Outcome | Boys | Girls |
|---|---|---|
| Mean age at activation of central pubertal development by increase in FMV total U-LH (S-LH) | 10.3 | 10.5 |
| By S-LH | 10.3 | 10.6 |
S-FSH in six biochemically prepubertal girls with thelarche
- S-FSH range in the six girls
- 2.3 and 2.7 IU/L
- Significantly higher than in biochemically and clinically prepubertal girls aged 10-12 years
- P = 0.039
- Significantly lower than in biochemically and clinically pubertal girls
- P = 0.018
Original publication
Utility of First-Morning-Voided Urinary Total Luteinizing Hormone in Detecting the Onset of Central Puberty. Horm Res Paediatr. Published 5 November 2024. doi:10.
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