Pubertal Girls With Overweight/Obesity Have Higher Androgen Levels—Can Metabolomics Tell us Why?
An erratum to this article was published (J Clin Endocrinol Metab, 15 Oct 2024 ↗)
Authors' conclusion
Metabolomic analyses of samples from pubertal girls did not identify an insulin resistance signature to explain the association between higher TBF and androgens. Instead, we identified potential novel signaling pathways that may involve raffinose or bile acid action at the adrenal gland.
Study context
- Population
- Pubertal, premenarchal girls aged 10.9 ± 1.39 SD years; 60% White, 24% Black, 16% other; 63% normal weight, 37% overweight/obeseavg 2.29 blood samples each
- Participants
- 66 participants
- Outcome
- Associations of BMI/total body fat and androgens with metabolomic features
Methodological detailsuntargeted metabolomics, liquid chromatography high-resolution mass spectrometry (MS), gaussian generalized estimating equation models, outcome lagged by one study visit, Benjamini-Hochberg false discovery rate (FDR) adjustment, enriched pathway analyses (RaMP-DB)
- Untargeted metabolomics
- Liquid chromatography high-resolution MS
- Gaussian generalized estimating equation models
- Outcome lagged by one study visit
- Benjamini-Hochberg FDR adjustment
- Enriched pathway analyses (RaMP-DB)
Main finding
As reported in the abstract
- Body mass index (BMI) and total body fat (TBF) were negatively associated with most features, incl. raffinose (a plant trisaccharide) and several bile acids
- For BMI, RaMP-DB identified many enriched pathways related to bile acids
- Androstenedione showed strong negative associations with raffinose and bile acids
Observational data: associations, not effects.
Original publication
Pubertal Girls With Overweight/Obesity Have Higher Androgen Levels—Can Metabolomics Tell us Why? J Clin Endocrinol Metab. Published 18 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →