Long‐Term Outcomes of Gonadotropin‐Releasing Hormone Analogue Therapy in Central Precocious Puberty: A Comparative Analysis of Obese and Normal‐Weight Girls
Authors' conclusion
GnRHa therapy had a beneficial effect on height gain in both CPP girls with overweight/obesity and normal weight. BMI SDSs at FH were less than those at diagnosis in both groups.
Study context
- Population
- Girls with idiopathic central precocious puberty (CPP) treated with gonadotropin-releasing hormone analogue (GnRHa) who had reached final height
- Participants
- 726 participants
- Exposure
- Overweight/obese vs normal-weight girls with CPP treated with GnRHa
- Overweight/obesen = 269
- Normal-weightn = 457reference
- Outcome
- Final height, BMI changes and age at menarche
Main finding
As reported in the abstract
Height gain (FH − initial predicted adult height) after GnRHa
P = 0.010
Observational data: associations, not effects.
Further findings
Bone age advancement at diagnosis
P < 0.001
Interval from GnRHa discontinuation to menarche
P = 0.961
Median
| Outcome | Overweight/obese | Normal-weight | P value |
|---|---|---|---|
| Height SDS at diagnosis | 1.53 (IQR 0.69–2.12) | 0.80 (IQR 0.28–1.40) | P < 0.001 |
| BMI SDS at FH (vs at diagnosis: Overweight/obese 1.70 (1.23, 2.51); Normal-weight 0.26 (−0.35, 0.67)) · final height | 1.26 (IQR 0.52–2.07) | −0.23 (IQR −0.79–0.47) |
- Body mass index (BMI) standard deviation score (SDS) at final height (FH) (vs at diagnosis: Overweight/obese 1.70 (1.23, 2.51); Normal-weight 0.26 (−0.35, 0.67)) — BMI SDS at FH lower than at diagnosis in both groups
- p < 0.001
- BMI SDS at FH (vs at diagnosis: Overweight/obese 1.70 (1.23, 2.51); Normal-weight 0.26 (−0.35, 0.67)) — Overweight/obese girls with normalised BMI SDS at FH
- 109
Original publication
Long‐Term Outcomes of Gonadotropin‐Releasing Hormone Analogue Therapy in Central Precocious Puberty: A Comparative Analysis of Obese and Normal‐Weight Girls. Clin Endocrinol (Oxf). Published 30 July 2026. doi:10.
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