Prevalence of Polycystic Ovarian Syndrome in Girls with a History of Idiopathic Central Precocious Puberty
Authors' conclusion
Adolescent girls with a history of ICPP have an increased risk of PCOS. This risk seems not to be related to GnRHa treatment.
Study context
- Population
- Post-menarcheal girls with a history of idiopathic central precocious puberty (ICPP), evaluated at gynecological age ≥2.5 years
- Participants
- 94 participants
- Exposure
- Gonadotropin-releasing hormone analogue (GnRHa)-treated vs untreated ICPP girls; ICPP girls vs healthy adolescents
- GnRHa-treatedn = 63
- Outcome
- Prevalence of PCOS (adolescent criteria)
- Follow-up
- Gynecological age ≥2.5 years
Main finding
As reported in the abstract
PCOS prevalence in ICPP girls
Met diagnostic criteria for PCOS
12%
RR of PCOS in ICPP girls vs healthy adolescents
2.5
Observational data: associations, not effects.
Further findings
Menstrual disorders, clinical and biochemical hyperandrogenism (HA) in ICPP girls
- Menstrual disorders
- 29%
- Clinical HA
- 36%
- Biochemical HA
- 23%
BMI, menstrual dysfunction, hyperandrogenemia and clinical HA: treated vs untreated
- No difference in BMI, menstrual dysfunction or hyperandrogenemia between treated and untreated
- Higher proportion of clinical HA in untreated vs treated
Original publication
Prevalence of Polycystic Ovarian Syndrome in Girls with a History of Idiopathic Central Precocious Puberty. Horm Res Paediatr. Published 8 August 2023. doi:10.
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