Peak serum luteinising hormone cut‐off during gonadotropin‐releasing hormone analogue test for diagnosing central precocious puberty was lower in girls with obesity as compared with girls with normal weight
Authors' conclusion
Lower peak serum LH cut-off to 4 IU/L for diagnosing CPP in girls with OW/OB should be considered to avoid underdiagnosis of the condition.
Study context
- Population
- Girls with premature breast development who underwent subcutaneous gonadotropin-releasing hormone analogue (GnRHa) (100 µg of triptorelin acetate) test, classified as central precocious puberty (CPP) or premature thelarche600 with CPP
- Participants
- 971 participants
- Comparison
- Peak serum luteinising hormone (LH) during GnRHa test in girls with OW/OB vs normal weight (NW)
- OW/OBn = 337
- NWn = 634reference
- Outcome
- Peak serum LH cut-off for diagnosing CPP in girls with OW/OB
Methodological detailsmedical records review
- Medical records review
Performance
As reported in the abstract
Peak serum LH cut-off for CPP diagnosis
| Test or model | Value | Sensitivity | Specificity |
|---|---|---|---|
| NW | 5 IU/L | 75% | 90% |
| OW/OB | 4 IU/L | 86% | 93% |
Value
NW5 IU/L
OW/OB4 IU/L
Sensitivity
NW75%
OW/OB86%
Specificity
NW90%
OW/OB93%
Further findings
Peak serum LH concentration in CPP girls
- No differences in peak serum LH between CPP girls with NW and OW/OB
Original publication
Peak serum luteinising hormone cut‐off during gonadotropin‐releasing hormone analogue test for diagnosing central precocious puberty was lower in girls with obesity as compared with girls with normal weight. Clin Endocrinol (Oxf). Published 1 February 2024. doi:10.
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