Serum kisspeptin, neurokinin B and inhibin B levels can be used as alternative parameters to distinguish idiopathic central precocious puberty (CPP) from premature thelarche in the early stages of puberty
Main finding · Serum kisspeptin, NKB, INHB and AMH levels; differentiation of CPP from PTResult — go to the resultAUC 0.819Authors' conclusion
We, first showed in the same patients' group that serum kisspeptin, NKB and INHB were higher in patients with CPP and can be used as alternative parameters to distinguish CPP from PT.
Study context
- Population
- Girls with breast development starting before 8 years (CPP or PT) and age-matched healthy prepubertal girls; Gonadotropin-releasing hormone (GnRH) stimulation test in all with early breast development
- Participants
- 51 / 48 / 42
- Exposure
- CPP vs PT vs healthy prepubertal controls
- CPPn = 51
- PTn = 48
- Prepubertal controlsn = 42reference
- Outcome
- Serum kisspeptin, NKB, AMH and INHB levels and their diagnostic validity for CPP
Main finding
As reported in the abstract
Serum kisspeptin, NKB, INHB and AMH levels; differentiation of CPP from PT
AUC
0.819
P < 0.001
Observational data: associations, not effects.
Further findings
Age
Age
- No statistically significant difference in mean age
Correlations
- Serum kisspeptin, neurokinin-B (NKB) and inhibin B (INHB) positively correlated with bone age (BA) advancement and peak LH in GnRH test
Original publication
Serum kisspeptin, neurokinin B and inhibin B levels can be used as alternative parameters to distinguish idiopathic CPP from premature thelarche in the early stages of puberty. Clin Endocrinol (Oxf). Published 15 March 2023. doi:10.
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