Evaluation of Serum Adipokine Levels in Girls With Central Precocious Puberty
Authors' conclusion
In our study, we found that Omentin-1 level decreased and Chemerin level increased in lean girls with CPP. More studies are needed to elucidate how adipokines play roles in explaining the onset of CPP, and whether they may be used as a reliable marker for the diagnosis of CPP.
Study context
- Population
- Girls with central precocious puberty and controls
- Participants
- 105 participants
- Comparison
- Girls with central precocious puberty (CPP) vs controls
- CPPn = 53
- Controln = 52reference
- Outcome
- Serum adipokine levels (Visfatin, Omentin-1, Chemerin) and their utility in diagnosis of CPP
Main finding
As reported in the abstract
Omentin-1 cut-off ≤ 48.9 for CPP diagnosis: sensitivity / specificity
81% / 54%
Chemerin cut-off ≥ 417 for CPP diagnosis: sensitivity / specificity
85% / 60%
Observational data: associations, not effects.
Original publication
Evaluation of Serum Adipokine Levels in Girls With Central Precocious Puberty. Clin Endocrinol (Oxf). Published 16 September 2024. doi:10.
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