Long-Acting Gonadotropin-Releasing Hormone Analogues for Central Precocious Puberty, Including 45-Mg 6-Month Subcutaneous Leuprolide Acetate: Use for Treatment and Treatment Monitoring
Authors' conclusion
Compared to IM LA and triptorelin, long-acting SC LA shows similar burst kinetics and rapid LH rise after the first dose, followed by similar suppression of LH and sex steroids after subsequent doses. Since IM LA and triptorelin have demonstrated usefulness that is comparable to that of traditional GnRH stimulation testing for monitoring CPP, we presume that SC LA may be similarly employed.
Study context
- Population
- Children with central precocious puberty treated with GnRH analogues155 girls
- Participants
- 162 children
- Comparison
- SC LA vs IM LA for central precocious puberty (CPP) treatment monitoring
- Outcome
- Peak LH after subsequent doses
Methodological detailsliterature search (PubMed, Embase, CINAHL), 5 studies selected, new unpublished data from the original phase 3 trial
- Literature search (PubMed, Embase, CINAHL)
- 5 studies selected
- New unpublished data from the original phase 3 trial
Main finding
As reported in the abstract
IM LA
2.7
mean · IU/L
SC LA
0.2
± 0.02 · IU/L
- SC LA achieved sex-steroid hormone suppression
- >98%
Original publication
Long-Acting Gonadotropin-Releasing Hormone Analogues for Central Precocious Puberty, Including 45-Mg 6-Month Subcutaneous Leuprolide Acetate: Use for Treatment and Treatment Monitoring. Horm Res Paediatr. Published 23 April 2024. doi:10.
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