Growth Hormone Therapy: Comparison of Short- and Long-Term Outcomes between Children with Growth Hormone Deficiency and Small for Gestational Age
Authors' conclusion
In contrast to GHD, we observed practically no relationship between 1st-year and long-term outcomes in SGA patients treated with GH.
Study context
- Population
- Children with growth hormone deficiency (GHD) or small for gestational age (SGA) treated with GH therapy at a tertiary centre
- Participants
- 103 vs 53
- Exposure
- GH therapy outcomes in GHD vs SGA
- GHDn = 103
- SGAn = 53reference
- Outcome
- Delta height SDS after 1 year of treatment
- Follow-up
- 1 year
Methodological detailssingle-centre, multivariable linear regression adjusted for age, sex and height at therapy start
- Single-centre
- Multivariable linear regression adjusted for age, sex and height at therapy start
Main finding
As reported in the abstract
GHD
0.90
mean · CI 0.82–0.99 · standard deviation scores (SDS)
SGA
0.67
mean · CI 0.54–0.79 · SDS
P = 0.003
Observational data: associations, not effects.
Further findings
| Outcome | GHD | SGA | P value |
|---|---|---|---|
| Increase in height SDS at final height (FH)Higher in GHD | mean 2.21 (CI 2.00–2.42) SDS | mean 1.05 (CI 0.75–1.35) SDS | P < 0.001 |
| Target height corrected FH · final height | −0.39 (CI −0.62–-0.15) SDS | −1.22 (CI −1.57–-0.87) SDS | P < 0.001 |
| Relation between short-term and long-term outcomes (adjusted R2)Relation in GHD but not in SGA | adjusted R2 0.66 | adjusted R2 0.01 |
Sex-specific long-term outcome
- Girls with GHD and boys with SGA had a better long-term outcome than the opposite sex
Delta height cut-off 0.5 SDS in first year to detect long-term non-responders
- Low sensitivity
Original publication
Growth Hormone Therapy: Comparison of Short- and Long-Term Outcomes between Children with Growth Hormone Deficiency and Small for Gestational Age. Horm Res Paediatr. Published 18 April 2024. doi:10.
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