Physiology and diagnostic potential of beta-hydroxybutyrate in neonatal glycemia—a prospective cohort study
Authors' conclusion
Neonates with hypoglycemia risk factors and those receiving formula developed less ketonemia.
Study context
- Population
- Neonates with and without hypoglycemia risk factors, single-centre tertiary hospital, 05/2020–09/2022516 with BOHB at ≥24 h
- Participants
- 895 neonates
- Exposure
- Neonates with vs without hypoglycemia risk factors; feeding regimens
- At-riskn = 752
- Controlsn = 143reference
- Outcome
- Comparison of BG and combined BG + BOHB values and percentiles across risk factors and feeding regimens; ketonemia defined as BOHB >0.5 mmol/L
Methodological detailssingle-centre, tertiary hospital, standardized blood glucose (BG) and BOHB measurements
- Single-centre
- Tertiary hospital
- Standardized BG and BOHB measurements
Main finding
As reported in the abstract
Ketonemia (BOHB >0.5 mmol/L) · ≥24 hours of age
P = 0.023
- Ketonemia overall among 516 neonates with BOHB at ≥24 h
- 107 (20.7%)
Observational data: associations, not effects.
Further findings
Ketonemia by feeding regimen · ≥24 hours of age
P < 0.001
Original publication
Physiology and diagnostic potential of beta-hydroxybutyrate in neonatal glycemia—a prospective cohort study. J Clin Endocrinol Metab. Published 27 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →