Pediatric endocrinology

Systematic review of guidelines on neonatal hypoglycemia

Clin Endocrinol (Oxf)Published Systematic review of clinical guidelines

Authors' conclusion

By summarising the recommendations in the guidelines on neonatal hypoglycemia, we found that blood glucose values were not the only observational indicator, and other indicators (e.g., ketone bodies, lactate) related to glucose metabolism should also be considered for a comprehensive assessment. There is still a lack of consensus on thresholds for the clinical management of hypoglycemia and target glucose ranges for its control, and the recommendations on its pharmacotherapy are rather simple and sketchy. In the future, more high-quality studies are required to further improve the early identification of neonatal hypoglycemia and intervention strategies against it.

Study context

Population
Clinical guidelines on neonatal hypoglycemia from different countries and regions10 guidelines
Outcome
Guideline quality (AGREE-II) and content
Methodological detailsAGREE-II appraisal, two independent reviewers, Four appraisers assessed the guidelines using AGREE-II
  • AGREE-II appraisal
  • Two independent reviewers
  • Four appraisers assessed the guidelines using AGREE-II

Pooled result

As reported in the abstract

Mean AGREE-II score across six domains

45.28%-83.45%

Original publication

Systematic review of guidelines on neonatal hypoglycemia. Clin Endocrinol (Oxf). Published 24 November 2023. doi:10.1111/cen.14995

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