Glucose pattern in children with classical congenital adrenal hyperplasia: evidence from continuous glucose monitoring
Authors' conclusion
Continuous glucose monitoring demonstrated a disrupted daily glucose pattern in children with CAH, paralleled by a lower cortisol concentration.
Study context
- Population
- Children with genetically diagnosed classical congenital adrenal hyperplasia (CAH) on hydrocortisone and fludrocortisone replacement; 6 female; age 3.1 years [1.4, 5.1]; BMI 17.3 kg/m² [15.6, 17.9]7 had continuous glucose monitoring (CGM) and cortisol/adrenocorticotropic hormone (ACTH)
- Participants
- 11 children
- Exposure
- Daytime time slots
- Outcome
- Percentage of time with sensor glucose <70 mg/dL by daytime slot
Methodological detailsinpatient 24 h serial cortisol and ACTH measures, two 14-day CGM sessions
- Inpatient 24 h serial cortisol and ACTH measures
- Two 14-day CGM sessions
Main finding
As reported in the abstract
% time sensor glucose <70 mg/dL
10 Pm-7 Am vs 4 Pm-10 Pm: P = 0.006 · 7 Am-4 Pm vs 4 Pm-10 Pm: P = 0.003
Observational data: associations, not effects.
Further findings
Nighttime hypoglycemia below 65 mg/dL
- Nighttime hypoglycemia mostly spent below 65 mg/dL
- 10.9% [4.1, 34]
Cortisol nadir at 7 Am
- Glycemic pattern paralleled daily cortisol nadir at 7 Am
- 10.3±4.4 μg/dL
Association of time in hypoglycemia with cortisol
- Greater % time in hypoglycemia associated with lower cortisol at 7 Am
- P < 0.001
- Greater % time in hypoglycemia associated with lower cortisol at 10 Pm
- P = 0.005
Original publication
Glucose pattern in children with classical congenital adrenal hyperplasia: evidence from continuous glucose monitoring. Eur J Endocrinol. Published 11 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →