Lambda-Mu-Sigma (LMS)-based continuous pediatric reference values for soluble receptor activator of nuclear factor kappa B ligand (Soluble RANKL (sRANKL)) and osteoprotegerin (OPG) in the HARP cohort
Authors' conclusion
This is the first report of LMS-based continuous pediatric reference percentiles for sRANKL, OPG and sRANKL/OPG ratio that allows calculation of standardized patient z-scores to assess bone metabolic turnover in children.
Study context
- Population
- Children aged 0.1–18 years, HAnnover Reference values for Pediatrics (HARP) study166 boys
- Participants
- 300 children
- Outcome
- LMS-based continuous reference percentiles for sRANKL, OPG and sRANKL/OPG ratio
Methodological detailsLMS-based continuous reference percentiles, sRANKL and OPG assessed by ELISA; percentiles generated using RefCurv software
- LMS-based continuous reference percentiles
- sRANKL and OPG assessed by ELISA; percentiles generated using RefCurv software
Main finding
As reported in the abstract
LMS-based reference percentiles for sRANKL, OPG and sRANKL/OPG ratio
- Percentiles for sRANKL, OPG and sRANKL/OPG ratio all age-dependent
- sRANKL and sRANKL/OPG associated with sex
- Boys: sRANKL percentiles highest in infancy, continuous decline until age 7 years, second peak around age 12-13 years
- Girls: continuous slow decline of sRANKL percentiles from infancy until age 13 years, then rapid decline until adulthood
- OPG percentiles continuously declined from infancy to adulthood
- sRANKL/OPG ratio percentiles paralleled those of sRANKL
Further findings
Correlates of sRANKL and OPG
- Serum sRANKL correlated with OPG and serum phosphate z-scores
- P < 0.05
- OPG inversely associated with standardized body weight, BMI and urinary phosphate to creatinine ratio
- P < 0.05
Original publication
LMS-based continuous pediatric reference values for soluble receptor activator of nuclear factor kappa B ligand (sRANKL) and osteoprotegerin (OPG) in the HARP cohort. Osteoporos Int. Published 9 November 2023. doi:10.
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