Priming short children with sex steroids prior to growth hormone testing decreases the frequency of divergent results
Authors' conclusion
Sex steroid priming prior to GH testing is well tolerated, enhances spontaneous nocturnal GH secretion, and reduces the frequency of divergent results between spontaneous and stimulated values. We recommend incorporating priming when evaluating children in prepuberty or early puberty for suspected GHD. </p>.
Study context
- Population
- Short children who underwent a nocturnal spontaneous growth hormone (GH) secretion test followed by an arginine-insulin stimulation test over 30 years, Department of Pediatrics, Örebro University Hospital, Sweden
- Participants
- 132 children
- Exposure
- Sex steroid priming vs no priming before GH testing
- Primedn = 25
- Outcome
- Divergent results between spontaneous and stimulated GH tests
Methodological detailsretrospective chart review, single-centre
- Retrospective chart review
- Single-centre
Main finding
As reported in the abstract
Divergent results between the two GH tests
P = 0.027
Observational data: associations, not effects.
Further findings
Peak spontaneous GH · higher with Primed
P = 0.042
Mean spontaneous GH · higher with Primed
P = 0.007
Safety
- Mild adverse events · short-term — Primed
- 12%
Original publication
Priming short children with sex steroids prior to growth hormone testing decreases the frequency of divergent results. Horm Res Paediatr. Published 10 June 2025. doi:10.
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